You can't live without NAD+.

The bad news: NAD+ levels are destroyed by aging, inflammation, diet, stress, and sickness. This leads to weakness, frailty, and even faster aging.

The good news: You can help restore your NAD+ levels with exercise, nutrition, and targeted supplement formulas.

NAD+ precursor response is personal.

The enzymes that rebuild your NAD+ stores vary by person and tissue, so the same supplement doesn’t always produce the same effect.

Supporting multiple pathways with NMN, NR, and Trigonelline helps you get reliable, steady NAD+ support without guesswork.

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The comprehensive NAD+ biosynthesis solution.

Liposomal delivery means greater bioavailability.

Liposomal delivery wraps sensitive ingredients like NMN and NR in phospholipids, the same fats that make up cell membranes, so they’re protected during digestion and first-pass liver processing.

This translates to more of the active ingredients reaching your cells where you need them most, and more powerful effects at significantly lower doses.

The Roles of NAD+

  • Energy Metabolism

    NAD+participates in the reactions that turn food into ATP inside mitochondria. It also supports the electron transport chain, which fuels nearly every cellular function.

  • DNA Access & Repair Signaling

    NAD+is consumed by PARP enzymes involved in the cellular response to everyday DNA stressors. Sustaining NAD+helps ensure these maintenance pathways have the coenzyme they need.

  • Sirtuin Activity

    Sirtuins rely onNAD+to influence cellular housekeeping, metabolic signaling, and chromatin regulation—factors tied to how cells adapt to stress and maintain efficiency.

  • Mitochondrial Function

    NAD+availability supports pathways that help mitochondria produce energy efficiently and manage oxidative workload.
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      How NMN supports NAD+

      Supplemental NMN supplies a direct building block for the body’sNAD+salvage pathway.

      Absorption & use: NMN is absorbed and utilized to help sustain healthy, youthful NAD+ production.

      Conversion: Inside cells, enzymes (including NMNAT) convert NMN into NAD+.

      Cellular support: By supporting NAD+ availability, NMN helps power energy metabolism and NAD+-dependent housekeeping pathways (PARPs, sirtuins).

    Why NMN belongs in your daily routine.

    By promoting healthy NAD+ levels, NMN helps:

    Support steady energy metabolism by feeding mitochondrial pathways.

    Support DNA maintenance signaling, which relies on NAD+.

    Support sirtuin-linked longevity pathways involved in cellular housekeeping.

    Together with sleep, protein intake, movement, and sunlight, NMN offers a science-grounded way to support healthy aging from the cellular level up.

    Supports Energy Metabolism

    NAD+participates in the reactions that turn food into ATP inside mitochondria. It also supports the electron transport chain, which fuels nearly every cellular function.

    Supports Brain-Health Cellular Pathways

    NAD+is consumed by PARP enzymes involved in the cellular response to everyday DNA stressors. Sustaining NAD+helps ensure these maintenance pathways have the coenzyme they need.

    Supports DNA Maintenance & Cellular Health

    Sirtuins rely onNAD+to influence cellular housekeeping, metabolic signaling, and chromatin regulation—factors tied to how cells adapt to stress and maintain efficiency.

    Supports Vascular & Endothelial Function

    NAD+availability supports pathways that help mitochondria produce energy efficiently and manage oxidative workload.

    Supports Metabolic Flexibility

    Sustaining healthyNAD+helps the cellular machinery that coordinates how we use and switch among fuel sources from food.

    PURE CRYSTALLINE NMN 

    Our NMN Powder is 100% pure crystalline Nicotinamide Mononucleotide, designed for absorption under the tongue for superior bioavailability compared to regular capsules.

    Why NMN is helpful for healthy aging.

    Aging involves cumulative cellular work: oxidative load, DNA maintenance, and changing inflammatory tone, all of which increase demand forNAD+. When supply lags behind demand, cells may struggle to keep pace. Damage can accumulate and cells may struggle between repair and normal daily functions.

    Bridging the NAD+ gap with NMN.

    LowerNAD+availability can contribute to sluggish energy, slower bounce-back after activity, and less adaptable metabolism.

    Adding NMN supplies precursor material your cells can use to sustainNAD+, helping to:

    • Re-energize mitochondrial pathways for day-to-day vitality.
    • Support DNA maintenance workflows that rely on NAD+.
    • Activate NAD+-dependent housekeeping linked to healthy aging.
    • Support overall immune readiness within normal, healthy reactions.
    • Encourage metabolic flexibility as part of a balanced routine.

    Pure and effective: why choose Renue Pure NMN Powder?

    High purity: 99.9% NMN, independently verified; no fillers or flow agents.

    Quality you can verify: COA for every lot; identity and purity confirmed (HPLC/NMR); screened for heavy metals and microbes.

    Manufactured under cGMP: Consistent processes and batch traceability.

    Easy and versatile: Mix with water; some customers prefer to hold under the tongue before swallowing.

    Storage: Tightly closed; cool, dry place; no refrigeration required.

    Full 3 month supply in 1 jar: take one (1) level scoop twice daily. Taking 2 doses per day, 100g will last over 3 months.

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      Build your NAD +  reserves.

      • The Problem: Your body makes NAD+ through multiple routes, but they all decline with age. The main recycling pathway, using an enzyme called NAMPT, gets overwhelmed.¹⁴
      • The Solution: Supply multiple NAD+ precursors that use different pathways:
      • NMN: Uses the Salvage pathway, most direct route.
      • NR: Uses the NR Kinase pathway, the backup route.
      • Trigonelline: Uses the Preiss-Handler pathway, the third option.
      • Direct NAD+: Gets broken down and rebuilt.

    Human signals:

    Research Shows:SteadyNAD+levels throughout the day, supporting consistent energy and cellular function.

    NMN (metabolism & muscle): 250 mg/day for 10 weeks improved muscle insulin sensitivity and increased circulating NAD+-related metabolites in postmenopausal adults with impaired glucose regulation.

    NMN (capacity & blood NAD+): 250 mg/day for 12 weeks increased whole-blood NAD+ and produced small gains in gait speed and grip strength in healthy older men.

    NMN (vascular structure): 12 weeks increased NAD+ metabolites and improved arterial stiffness in participants with higher baseline stiffness.

    NR (blood & cardiovascular): 1,000 mg/day elevated the blood NAD+ metabolome and showed exploratory reductions in systolic BP/aortic stiffness in older adults.

    Trigonelline (muscle function): translational work links it to NAD metabolism and age-related muscle function; early human-relevant signals.

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      Who Benefits Most from NAD+ Restoration?

      While everyone over 30 has declining NAD+, certain people see more dramatic improvements:

      • High Performers: Entrepreneurs, athletes, parents juggling careers and kids: people who need sustained energy see immediate benefits from optimized NAD+ levels.
      • The Metabolically Challenged: If you have insulin resistance, metabolic issues, or stubborn weight, NAD+ restoration improves how cells handle glucose and burn fat.
      • Poor Sleepers: Those who wake exhausted despite adequate sleep often have impaired cellular regeneration. NAD+ restoration can improve sleep quality at the cellular level.
      • Chronic Stress Cases: Stress depletes NAD+ faster.³⁴ If you're in a demanding phase of life, you're burning through NAD+ at an accelerated rate.
      • Anyone Over 45: This is when NAD+ decline accelerates. The difference between supplementing and not becomes increasingly apparent with each passing year.
      • The Biohacker Curious: If you're already optimizing diet, exercise, and sleep, NAD+ is the next logical frontier: it amplifies everything else you're doing.

    Common Questions.

    Can't I just take NMN?

    You can, but you're leaving 75% of the benefits on the table. It's like having a sports car but only using first gear.

    How long until I feel results?

    Most people notice energy improvements in 3-7 days. Deeper benefits (recovery, cognitive, metabolic) typically emerge by week 3-4.

    Is this safe long-term?

    Every ingredient has extensive safety data in human and animal models. Our dosing strategies reflect the standards set by researchers for safe use.

    This sounds too good to be true

    It would be if we were claiming one pill fixes everything. We're not. This is about systematically addressing multiple failure points in a well-studied biological system. The research is published in Science, Nature, Cell, established scientific journals, not wellness blogs.

    Why doesn't my doctor know about this?

    Medical education focuses on disease treatment, not optimization.NAD+biology has exploded in the last decade. Most physicians trained before this research emerged, and even if it was covered, most doctors aren’t focused on longevity as a subspecialty. Additionally, you can't patentNAD+or its precursors since they’re natural molecules and are made inside the body, so there's limited pharmaceutical interest in education for funding reasons.

    Does this just make expensive urine?

    Valid concern. RawNAD+precursors without supporting pathways can have poor utilization. That's exactly why the four-pathway approach exists: to ensure what you take gets used, not excreted. The PROTECT pathway specifically addresses this by reducing wasteful consumption.

    What about side effects?

    At physiological doses, side effects are minimal. Some people experience initial sleep changes (as circadian rhythms adjust), or digestive changes (as the microbiome adapts). These typically resolve within days. Start low, increase gradually. Always check for ingredient interactions if you're on prescriptions or are under the care of a physician.